The story picks up later that night from the previous film at LAX, as passengers board a flight to Nashville. When a passenger becomes violently ill with a mysterious rabies-like virus, the plane makes an emergency landing at a large metropolitan airport. Jenny (Mercedes Masohn), a heroic yet inexperienced flight attendant, takes charge of the safety of her passengers.
Relieved when a swarm of heavily equipped emergency vehicles, police units and the CDC arrive, Jenny and the passengers soon discover that they have been quarantined and are now trapped. Desperate to escape, Jenny enlists the help of one of the surviving passengers, a kindergarten teacher, Henry (Josh Cooke), to devise a plan to survive."
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