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Confirmed recently that the studio was moving forward with a sequel and plan to somehow have Will Smith return as "Robert Neville." This project was originally announced several years ago as a prequel, but I guess plans fell through and now they're pursuing a sequel. You can check the details area on UHM's page for more info on the project:
http://www.upcominghorrormovies.com/movie/i-am-legend-2
I kinda liked the first flick, but felt the horrible CG really ruined the movie for the most part. I'm open to a sequel though, and hopefully they do something 'bout that shitty CG this time