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I'd bet on L4D3 taking place either in LA or possibly following off some sort of nonsensical adventure with the Midnight Riders whom are pretty popular in L4D2.
As far as some tidbits on the game. I love the new update they put out recently for bot infected for versus and for manual ghost spawns on finales. Especially the second part of that which was long overdue.
Still a campaign finale like Dark Carnival needs some work. No ladder on the corner that survivor teams usually camp and the back area up top that you should be able to spawn in which you can't if survivors stand in front of the gate. Even though there is plenty of space in the back area to warrant spawning.
Melee on Tank damage decreased from 10% to 5% and it seems better on normal versus but very little difference is noticed on the 8v8 servers I play on. A good tank player ends up equating to hiding, throwing rocks and letting the rest of the specials do the work. Especially on a campaign like Dark Carnival, hit up the concert roof and let them do damage.