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The first Prey was a bit of an underrated game that seemed to go under the radar for most people, but it was a surprisingly entertaining and creative FPS, especially with the use of creating portals/rips to travel through and walking on walls and ceilings, both of which weren't seen much in FPS at the time it came out.
Apparently a sequel has been in development for some time and will be coming out in 2012. From the interview below, it seems like it will be going for more of an open world, RPG-type theme. I'm excited to see what the creators have in stored for us this time 'round.